The benefits of HGH increasing lean muscle mass while also promoting the rapid loss of adipose fat. It has been shown to increase the efficiency of the metabolism, resulting in a “fat burning” effect. It does not replace a sound diet but it maximizes the benefits of one.
Numerous studies have documented the metabolic effects of IGF1 as mediated by growth hormone. A 2013 review of 23 clinical studies (see below) concluded that growth hormone had benefits for body composition and lipid profiles, with no adverse effects.
Treatment with biosynthetic GH has been shown to improve the body composition and the metabolic efficacy of lean body mass in obese patients undergoing therapeutic severe caloric restriction. GH and conceivably GHRPs might therefore have a place in the therapy of obesity.
University of Milan, IRCCS Ospedale San Luca, Istituto Auxologico Italiano, Italy.International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity [1999, 23(3):260-271]
Response in weight and BMI was greater in men than in women, whereas women showed greater improvement in QoL than men.
Our findings indicate that baseline and 24 months, IGF1 and its degree of increase during GH replacement were more important than stimulated peak GH to predict the phenotypic response.
2013 Study of benefits (weight, BM1, cholestrerol)
Feldt-Rasmussen U, Brabant G, Maiter D, Jonsson B, Toogood A, Koltowska-Haggstrom M, Rasmussen AK, Buchfelder M, Saller B, Biller BM
Department of Medical Endocrinology, PE 2132, Rigshospitalet, National University Hospital, Copenhagen University, Copenhagen, Denmark. email@example.com
European Journal of Endocrinology / European Federation of Endocrine Societies [2013, 168(5):733-743]
We included 23 prospective studies with a rhGH treatment duration ranging from 5 to 15 years. Overall, beneficial effects were reported on QoL, body composition, lipid profile, carotid intima media thickness and bone mineral density. In contrast, the prevalence of the metabolic syndrome, glucose levels, BMI and muscle strength were not, or negatively, influenced.
CONCLUSION: rhGH treatment in adult GHD patients is well-tolerated and positively affects QoL in the long term. However, the metabolic and cardiovascular effects during long-term treatment are variable. The low numbers of long-term studies and studied patients and lack of control data hamper definite statements on the efficacy of prolonged treatment. Therefore continuous monitoring of the effects of rhGH replacement to enable an adequate risk-benefit analysis that may justify prolonged, potentially life-long, treatment is advisable.
2013- Summary of Research
Appelman-Dijkstra NM, Claessen KM, Roelfsema F, Pereira AM, Biermasz NR
Department of Endocrinology and Metabolic Diseases C4-R and Center for Endocrine Tumors, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. firstname.lastname@example.org
European Journal of Endocrinology / European Federation of Endocrine Societies [2013, 169(1):R1-14]
Wallymahmed ME, Foy P, Shaw D, Hutcheon R, Edwards RH, MacFarlane IA. 1997Quality of life, body composition and muscle strength in adult growth hormone deficiency: the influence of growth hormone replacement therapy for up to 3 years. Clin Endocrinol (Oxf). 47:439–446
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